Cialis Onset of Action: How to Take Cialis for Best Results

Cialis is a medication used to manage male Erectile Dysfunction and Impotence. US-based pharmaceutical enterprise, Lilly, introduced it as the third oral therapy for that condition in 2003 after it gained US FDA approval. It is a drug that has steadily risen in popularity, raking in over a billion dollars in annual sales, and is only eclipsed sales-wise by Pfizer’s ED offering: Viagra. The drug is available in yellow almond-shaped tablets of 2.5 milligrams, 5 milligrams, 10 milligrams, and 20 milligrams.

Like Levitra, Staxyn, and Viagra, Cialis is an effective ED therapy because of its capability to inhibit phosphodiesterase type-5 in the corpus cavernosum, so that it is incapable of attacking cyclic guanosine monophosphate, which in turn relaxes penile smooth muscles and expands the blood vessels. In spite of this similarity, Cialis has been able to stand out because of some significant differences in its formula compare to those other drugs. While other ED drugs remain active for roughly 4 to 6 hours, it has the distinction of lasting for up to 36 hours after consumption. How is this possible?

Tadalafil And Cialis Half-Life Chart

Cialis contains the PDE5 inhibitor known as Tadalafil, which is the active pharmaceutical ingredient contained in the medication. Its distinctive quality is its half-life of 17.5 hours, which makes it last four times as long as Viagra (Sildenafil Citrate) and Levitra (Vardenafil). Apart from that it also becomes effective within a much shorter window than those two medications. Taking the medication thirty minutes before sexual activity is enough time.

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The major reason Cialis is able to last for thirty-six hours after consumption is that Tadalafil slowly withdraws from the body. Studies have demonstrated that about two hours after application, this active pharmaceutical ingredient attains peak plasma levels. What this means for Erectile Dysfunction patients, although it is not easily discernible, is that the ingredient is at its highest level of concentration between one to six hours after consumption.

The 20 milligrams dose is the one that lasts thirty-six hours after consumption. So, the ubiquitous alias for this medication, the ‘weekend pill’, is only applicable to the highest recommended dose. Having said that, treatment is typically started with the lowest dosage strength: the 2.5 milligrams dose. With all of this in mind, how can you get the most out of Cialis? Let us consider the answer to that question.

How To Get Maximum Effect From Cialis

First and foremost, it is best that you see a qualified doctor to ascertain what dose is right for you and get a prescription, since this is prescription-only medication. The doctor will, no doubt, perform a physical examination if you are suffering from Erectile Dysfunction. After that, he will make the determination of whether or not to recommend Cialis to you based on your medical history, contraindications, and drug interactions.

That is the best way to learn about hypersensitivity reactions, and substances contraindicated for concomitant administration with Tadalafil. These include any form of organic nitrates or nitric oxide donors, Alpha-blockers and Anti-hypertensives, Guanylate Cyclase Stimulators, Cytochrome P450 3A4 (CYP3A4), and other phosphodiesterase-5 inhibitors. If Cialis is the recommended medication, you want to get the maximum effect from it.

One way to take advantage of the sexual spontaneity that comes with ‘the weekend pill’ is to take advantage of the hours during which Tadalafil concentration is highest. As we mentioned earlier this window is between one to six hours after consumption. This is even more so if your doctor recommended the 20 milligrams dosage strength. If you expect to be involved in sexual activity by midnight, taking Cialis around 10 pm is actually a great idea. That is when Tadalafil will be at its peak level in your plasma.

Unlike Levitra, Staxyn, and Viagra, Food and alcohol haven’t been shown to hinder the effectiveness of Cialis in the bloodstream. The only substance you should watch out for is Grapefruit juice. Also, try not to go beyond the recommended dose once you have determined toleration. Tachycardia, Hypotension, Shortness of Breath, Facial and Limb Edema, Priapism, Sudden Loss of Hearing, Reduction in Visual Acuity, Arthritis, Stevens Johnson’s Syndrome, Paresthesia, Exfoliative Dermatitis, and Insomnia are some of the most severe side effects, which very rarely occur.

Conclusion

Cialis contains the PDE5 inhibitor known as Tadalafil, which is the active pharmaceutical ingredient contained in the medication. Its distinctive quality is its half-life of 17.5 hours, which makes it last four times as long as Viagra (Sildenafil Citrate) and Levitra (Vardenafil). That is why users have dubbed it ‘the weekend pill’ because if they take it on Friday, it remains active through Sunday. The major reason Cialis is able to last for thirty-six hours after consumption is that Tadalafil slowly withdraws from the body.

To get the maximum effect from Cialis you ought to start by consulting a qualified doctor to ascertain what dose is right for you and get a prescription, since this is prescription-only medication. The doctor will, no doubt, perform a physical examination if you are suffering from Erectile Dysfunction. After that, he will make the determination of whether or not to recommend Cialis to you based on your medical history, contraindications, and drug interactions.

Once you have acquainted yourself with the substances that you should avoid administering concomitantly with Cialis, you can take advantage of some of the facts revealed in the Cialis half-life chart produced by Lilly. For one thing, Tadalafil concentration is highest between one to six hours after consumption. Secondly, it reaches its peak level in the plasma after two hours. The only substance that has been demonstrated to hinder Tadalafil efficacy apart from those contraindicated is Grapefruit Juice. If you want to get this prescription drug or an effective generic version, see our TOP list of recommended online pharmacies.